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Senior Research Associate

Company: University of Colorado Anschutz Medical Campus
Location: Denver
Posted on: July 13, 2019

Job Description:

Please submit your application to this link: The Research Associate/Sr. Research Associate (RA) will operate the Multiplexed Ion Beam Imaging (MIBI) system and perform quality control processing of the data output. This scientist will work closely with a research team to develop high parameter immunohistology assays for the analysis of cells in tissue microenvironments, and with a data scientist to translate high-dimensional imaging data into biological insights. MIBI is an exciting new platform combining imaging with time-of-flight (TOF) mass spectrometry to generate simultaneous imaging of up to 50 biological targets. The ideal candidate for this position has experience with the construction, maintenance, operation, and validation of complex analytical instrumentation. This position will be part of the Human Immunology and Immunotherapy Initiative (HI3) at the University of Colorado School of Medicine. The mission of the HI3 is to develop the infrastructure to create an all-inclusive facility that provides experimental models for the preclinical testing of new candidate therapeutics, reliable immunotherapeutic production, consistent clinical trials research support, and organized immune monitoring capabilities. Under the HI3 umbrella, the human immune monitoring shared resource (HIMSR), uses state-of-the art instrumentation to facilitate blood and tissue sample processing and immune monitoring assays at the genomic, proteomic, and cellular level with the aim of monitoring patient responses to immunotherapy, discovering novel biomarkers for response to treatment, and identifying rationale for future combinatorial clinical trials in autoimmunity and cancer. The successful candidate for this RA position will be capable of maintaining and operating the MIBI instrument, and serve as the bridge between multiplexed stained tissue and complex data analysis on the multi-parametric quantitative imaging platform. Experience and background in mass cytometry, other TOF-MS systems, operation of high-resolution microscopes, and analysis of microscopy images are highly desired. A detail-oriented, well organized candidate that is able to work under supervision and in a team environment with excellent communication skills, who enjoys troubleshooting and is capable of following and creating Standard Operating Procedures (SOPs) for complex imaging analytical instruments is necessary. Professional FieldPhD in engineering, bioengineering, applied physics, or related field Supervision ReceivedYes, by the Director of HI3 Supervision ExercisedNone Examples of Work PerformedWork with our team to develop SOPs for MIBI imaging and analysis of tissue.Operate, manage, and maintain the MIBI instrument.Communicate with other research staff to understand tissue processing/staining SOPsCommunicate with principal investigators and other laboratory staff to develop optimal operating protocol for specific projectsTroubleshoot and communicate with MIBI service engineer in case of instrument malfunctionMaintain meticulous instrument calibration/monitoring recordsProcess imaging data (e.g. denoising) before handing data off for downstream analysisCompile experimental data for transfer to investigators and/or bioinformatician.Salary and BenefitsThe University of Colorado offers a full benefits package. Information on University benefits programs, including eligibility, is located at The University of Colorado Denver - Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees. The University of Colorado Denver - Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. The University of Colorado is committed to diversity and equality in education and employment. Benefits: Compensation Calculator: Diversity and EquityPlease click here for information on disability accommodations: University of Colorado Denver - Anschutz Medical Campus is committed to recruiting and supporting a diverse student body, faculty and administrative staff. The university strives to promote a culture of inclusiveness, respect, communication and understanding. We encourage applications from women, ethnic minorities, persons with disabilities and all veterans. The University of Colorado is committed to diversity and equality in education and employment. Qualifications Prerequisite Knowledge, Skills, and AbilitiesStrong mechanical aptitudeFamiliarity with Matlab, Python, Image J or other image processing softwareMinimum RequirementsOne year of experience working with complex analytical imaging instrumentation. PhD in engineering, bioengineering, applied physics, or related field. Preferred Qualifications2 years' work experience in a research setting with an emphasis in immunology-related experimentation1+ year of hands on experience with TOF-MS systems, ion beam systems, high-resolution microscopy systemsImage analysis and machine vision

Keywords: University of Colorado Anschutz Medical Campus, Denver , Senior Research Associate, Other , Denver, Colorado

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